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When iron and copper ions are released from proteins, they can contribute to the generation of OH, with certain chelators acting as enhancers and others functioning as inhibitors [228]

20 In a randomized controlled trial of patients with familial adenomatous polyposis, a 2 g daily dose of eicosapentaenoic acid (EPA) reduced the number and size of polyps by 2030%

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To identify gene sets enriched in samples showing synergistic effects compared with samples without synergistic effects, GSEA was performed using javaGSEA desktop application (GSEA v2.1.0) 27,28