Each specific image set from multiple acquisitions (GPX1, insulin and glucagon) was merged using Adobe Photoshop CS6 (Adobe Systems, San Jose, CA, USA)
2 Molecular mechanisms of ferroptosis Ferroptosis, a novel form of cell death distinct from apoptosis, pyroptosis and autophagy, is an iron-dependent programmed form of cell death characterized by an iron metabolism disorder, imbalance of the redox system and the accumulation of lipid peroxides ( Ferroptosis is an evolutionarily conserved process that occurs in mammals and various organisms (such as plants and microorganisms)
Counteracts catabolism and promotes anabolism
The current standard of care involves regular intravenous infusions of FIX, often administered multiple times a week or multiple times a month, according to the company
They contain unique secondary metabolites such as polysaccharides (notably -glucans), terpenoids, polyphenols, and peptides, which contribute to their immunomodulatory, antioxidant, anti-inflammatory, and antimicrobial properties [21]
