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Studied extensively in wound healing and anti-aging skin models

Lombardo F, Lunghi R, Pallotti F, Palumbo A, Senofonte G, Cefaloni AC, et al

When the subchondral bone is perforated, growth factors, damage-associated molecular patterns (DAMPs), and cytokines accumulate at the defect site, creating conditions that favor endothelial cell recruitment and vessel formation