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Bifidobacterium can convert deoxycholic acid, a bile acid, into UDCA through hydroxy sterol dehydrogenase, replenishing the bodys own UDCA

Therefore, in line with 3 R animal experimental principles, we chose to conduct our proof-of-concept study directly in elephants since an in-target-species trial in a real-world setting provides an accurate reflection of the vaccines safety and immunogenicity, avoiding reliance on models that poorly recapitulate elephant immunology

Treatment decreased glycolysis without affecting oxidative phosphorylation of the Th2 cells, significantly decreasing the levels of pyruvate and acetyl-CoA [207]