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Low SAM, excessive methylation demand, impaired creatine synthesis, reduced glutathione availability and oxidative stress may place additional strain on mitochondria, potentially contributing to fatigue, variable cognitive stamina, sensory sensitivity, poor stress tolerance and slow recovery from illness

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REM), TNF- (5.21 [17.68, 7.27] %

Compared to sgRNA controls, sg CBS significantly reduced intracellular cystathionine, cysteine, and GSH levels