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Besides, Chemotherapy (CT) and radiotherapy (RT) target rapidly dividing cells but still have significant normal tissue toxicity

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aureus adhesion and inflammatory responses ( Staphylococcus aureus in AD skin has also been shown to accumulate in keratinocyte lysosomes and trigger IL-1 secretion via TLR9 activation, thereby promoting inflammation (Moriwaki et al., 2019)

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UPR activation is particularly prominent in active MS lesions, driven by increased levels of inflammatory cytokines, reactive nitrogen species (RNS), and ROS