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Yu GF, Jie YQ, Wu A, Huang Q, Dai WM, Fan XF (2013) Increased plasma 8-iso-prostaglandin F2 concentration in severe human traumatic brain injury

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While this decline can be part of normal adaptive aging, it may become clinically relevant when combined with chronic circadian disruption, neurodegenerative processes, metabolic disease, or persistent oxidative and inflammatory stress