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Tirzepatide is a dual-agonist , meaning it works by targeting two hormones: GLP-1: helps regulate appetite, blood sugar, and digestion GIP: supports insulin response and reduces nausea Retatrutide is a triple-agonist , meaning it targets three hormones: GLP-1: helps regulate appetite, blood sugar, and digestion GIP: supports insulin response and reduces nausea Glucagon: affects energy use and fat metabolism Early studies show that retatrutide may be more successful than tirzepatide at managing diabetic kidney disease, as well as for weight control, while tirzepatide may be better at managing blood glucose

Due to these findings, GIP did not seem to be a therapeutic option for T2D or obesity (46, 47)

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4 Single-dose prefilled pens Lilly PACKAGE LABEL - Zepbound Prefilled Pen (Autoinjector) - 10 mg/0.5 mL Dose PACKAGE LABEL.PRINCIPAL DISPLAY PANEL NDC 0002-2471-80 Zepbound (tirzepatide) injection 10 mg/0.5 mL 4 x 10 mg/0.5 mL prefilled pens Rx Only For Subcutaneous Use Dispense enclosed Medication Guide to each patient

After your injection Carefully remove the needle and place it in a sharps container