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Injections can raise blood levels quickly and relieve deficiency symptoms, but they are not a validated weight-loss therapy for healthy adults

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Deficiency in this important nutrient can lead to fatigue, weakness, neurological symptoms, and other health concerns

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These may include: Conditions that increase the tendency for blood to clot (thrombophilia) Active cancer Some chronic conditions, including kidney disease, inflammatory bowel disease and autoimmune disease Recent surgery, especially major or orthopedic surgery Major trauma Prolonged lack of movement, such as bed rest or long periods of sitting or inactivity Congestive heart failure or chronic lung disease Serious infections, such as pneumonia, urinary tract infection or HIV Obesity Pregnancy Understanding these risk factors can help you and your care team have more informed conversations about prevention and follow-up care