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Vitamin C is also a potent anti oxidant, that along with GSH compete for removal of free radicals in the cell

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1,2 The IGFBPs may modulate the action of IGFs in several different ways: Inhibitory Model - IGFBPs prevent IGF/receptor association Enhancing Model - IGFBPs transport IGFs and facilitate binding with IGF receptors IGF Receptor-Independent Model - Product of direct IGFBPs/IGFBP receptor interaction Proteolytic Cleavage of IGFBP - Cleaved into lower affinity fragments which increases freely circulating, bioavailable IGF IGF-1 IGF-1 (Somatomedin C) is one of several growth factors necessary for normal human development

Mounting evidence positions redox imbalance not merely as a secondary phenomenon but as a primary driver of the disease continuum - from initial -cell dysfunction to devastating micro- and macro-vascular complications

Intravenous N-acetylcystine: the treatment of choice for paracetamol poisoning