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It is also worth noting that, consistent with other incretin-based and glucagon co-agonist therapies, small mean increases in heart rate were observed in the trial

Clinical monitoring should include: Periodic assessment of liver enzymes (ALT, AST) to detect transient increases

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But Mehmet Oz, his nominee to run the Centers for Medicare and Medicaid Services, is a physician and television personality who has endorsed GLP-1 drugs in a sponsored segment on his show and still promotes the drugs on his website, the Washington Post reported

Patients interested in medical weight loss should speak with a licensed provider about currently available options, including tirzepatide and semaglutide when clinically appropriate