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doi: 10.1111/j.1523-5378.2009.00686.x 44 DingSZMinoharaYFanXJWangJReyesVEPatelJet al

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This review highlights that for better success, VD deficiency needs to be corrected at multiple levels: (i) VD supplements and/or VD-rich foods need to be consumed to provide adequate VD, and (ii) the body needs to be able to upregulate VD-metabolizing genes to convert VD into 25(OH)VD and then to 1,25(OH)2VD to enhance its metabolic action