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Signs that you should hold include persistent nausea lasting more than seven days after a dose escalation, vomiting more than twice per week, diarrhea requiring dietary modification, or appetite suppression severe enough to prevent adequate protein intake

Tirzepatide is an ideal option for individuals who are struggling with obesity or excess weight, particularly those who have found it difficult to shed excess weight through dieting and working out on their own

These are consistent with NICE guidance and NHS recommendations, and are likely to remain relevant if retatrutide is eventually approved

An insulin syringe (U-100 or U-40) is strongly recommended because tirzepatide doses are small and require sub-millilitre precision

A1C reductions were largely maintained over time