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Klusa V, Beitnere U, Pupure J, Isajevs S, Rumaks J, Svirskis S, Dzirkale Z, Kalvinsh I (2013) Mildronate and its neuroregulatory mechanisms: targeting the mitochondria, neuroinflammation, and protein expression

This dual action appears to amplify appetite suppression and metabolic regulation beyond what GLP-1 activation alone produces, which is why clinical trials consistently show greater average weight loss with tirzepatide

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