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Safety Information, Contraindications, and Side Effects The following is drawn directly from Eden's official safety information page

If hypersensitivity reactions occur, discontinue use of RYBELSUS

The proportion of patients achieving at least 5% of clinically significant weight loss ranges from 37% to 47% for Lorcaserin, 35% to 73% for Orlistat, and 67% to 70% for the higher dose Of Phentermine plus extended release Topiramate