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Cytosolic Ca 2 dynamics are finely regulated by influx from intracellular organelles (vacuole, endoplasmic reticulum, mitochondria, plastids) and the plasma membrane via voltage-dependent, mechanosensitive, or ligand-activated channels, whereas efflux is mediated by Ca 2 -ATPases and Ca 2 /H antiporters

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The duration of treatment varies by route