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Reviewer information Nature Reviews Neuroscience thanks B

Its unusual stability in acidic environments sets it apart from most bioactive peptides and has made it a staple of repair-focused research

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Cell culture studies demonstrate increased expression of synaptic proteins including PSD-95, synaptophysin, and synapsin following Dihexa treatment, confirming molecular mechanisms underlying the observed synaptogenic effects

It is important to note that the participants in this trial were not experiencing clinical symptoms of vitamin B 12 deficiency