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Zeltina A, Bowden TA, Lee B

Retatrutide works as a triple receptor agonist, targeting three key hormonal pathways simultaneously: [1] [4] GLP-1 (glucagon-like peptide-1): Is thought to reduce appetite and slow gastric emptying GIP (glucose-dependent insulinotropic polypeptide): Is thought to enhance insulin secretion and may influence fat metabolism, though human evidence remains limited Glucagon receptor: Has been observed in early studies to increase energy expenditure and promote fat breakdown, though the clinical significance in humans is still being established This triple-action mechanism distinguishes retatrutide from currently approved dual or single agonists

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The weight maintenance after tirzepatide guide addresses the related question of sustaining results during and after the transition off active treatment