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The protective effects of semaglutide against various toxic stimuli, including high glucose, FFAs, cytokines and ROS, lead to the upregulation of antiapoptotic proteins, such as Bcl-2 and Bcl-xl, and the downregulation of proapoptotic proteins, such as Bcl-2-associated X protein (Bax), Bcl-2 antagonist of death (Bad) and caspases [46,196]

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Long-term shedding of SARS-CoV-2 is widely reported, even after resolution of symptomatic COVID-19

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Although RT increases several circulating growth factors that are important for brain health, this review will primarily focus on BDNF and IGF-1, given their prominent role in modulating brain plasticity