melanotic hyperpigmentation a Multiple brown macules on the labial mucosa of a patient with Smokers melanosis . Oral pigmentation

In a randomized, placebo-controlled study of 495 patients with intermittent claudication, 2 g/day of propionyl-L-carnitine for 12 months significantly increased maximal walking distance and the distance walked prior to the onset of claudication in patients whose initial maximal walking distance was less than 250 meters (m), but no effect was seen in patients who had an initial maximal walking distance greater than 250 m (65)

Resistance training twice weekly further protects against muscle loss

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Simpson JS, Garson MJ

EVOO also slowed early gastric emptying -- the same mechanism that GLP-1 drugs exploit to promote fullness