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Thats not all: A third, and perhaps the most interesting, potential cause is the low blood volume in ME/CFS patients

Several autophagy-related genes have been identified as positive regulators of ferroptosis, and blocking autophagy can inhibit the accumulation of ROS and ferroptosis [76]

The net result is a depolarization of the cell leading to the opening of voltage-gated calcium channels (L-type Ca 2+ channels) and Ca 2+ influx into the -cell