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A pilot study demonstrated that pioglitazone led to cognitive and metabolic improvements in patients with diabetes with AD or MCI [34]

Kulpa-Eddy JA, Taylor S, Adams KM

Contraindication Signals Standard conservative practice excludes anyone with active gastrointestinal disease, type 1 diabetes, prior pancreatitis, medullary thyroid carcinoma history, or active cancer from any retatrutide protocol

Retatrutide shows comparable HbA1c improvements in Phase 2 trials, but it lacks the comprehensive diabetes-specific trial data that tirzepatide possesses through the SURPASS program

Both promote angiogenesis through different pathways, creating additive effects on blood vessel formation