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While senescent cells are often discussed in the context of inflammatory signaling, their accumulation is fundamentally linked to impaired energy metabolism and oxidative stress

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This unique structure allows them to incorporate lipophilic (hydrophobic) molecules into their inner cavity, forming the so-called inclusion complexes

The pathway, not the molecule, is what determines legality

This failure is largely due to testing exclusively on cancer cell lines grown in liquid medium, a condition that predicts in vivo efficacy to anticancer drugs worse than cell culture in 3D gels [4, 5] and is far from adequately reflecting the therapeutic responsiveness of cancers within their native microenvironment [2, 3]