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128 Cyclosporine has been identified as a substrate for CYP3A4, P-glycoprotein (P-gp), and organic anion transporting polypeptides (OATPs), while also acting as a potent inhibitor of CYP3A4, multidrug resistance-associated protein 2 (MRP2), OATPs, P-gp, and breast cancer resistance protein (BCRP)

Increasing advancements in biocompatible polymers such as hyaluronic acid, chitosan, and carbomers are improving drug retention and therapeutic efficacy

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Intranasal delivery through the nose-to-brain pathway could theoretically decouple these effects

For Erysipelatoclostridium, every ASV mapped to [ Clostridium ] cocleatum