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What is measured in these rats and mice (and occasionally in small groups of human volunteers) is often not a hard endpoint like muscle strength or weight loss, but surrogate biomarkers: molecules in the blood that have an indirect link to a hard endpoint

When both are supported together, the body may be better positioned to maintain the metabolic function and DNA health that underlie long-term wellbeing

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These are common signs people bring up when they ask us about B12: Ongoing tiredness or low energy Trouble concentrating or remembering Pale skin Mood changes or irritability Feeling lightheaded or weak If several of these sound familiar, a simple blood test can help you and your provider decide on the next steps

Last updated on Sep 15, 2025