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For skin specifically, glutathione does two things that drive the widespread interest in it for skin brightening: Tyrosinase inhibition: glutathione reduces the activity of tyrosinase, the key enzyme responsible for melanin synthesis

doi:10.1586/14737175.2013.814930

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The E3-ubiquitin ligase NEDD4L stimulates the IB kinase complex (IKK) to be ubiquitinated and degraded