In gastric ulcer and colitis models (Sikiric et al
Representative designs include pH-responsive carriers, redox-sensitive disulfide systems, protease-responsive carriers activated by enzymes such as MMP-2 or MMP-9, and hypoxia-responsive systems based on oxygen-sensitive linkers, prodrugs or oxygen-modulating components [46, 47, 49, 84, 100]
9 Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
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