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Last reviewed: 2026-05-29

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When the system reaches the state with the lowest energy, the system is in thermodynamic equilibrium

Experimental studies in rodents and other small mammals consistently demonstrate that disruptions to normal light-dark cycles (e.g., via phase shifts, continuous light or darkness, or dim LAN) can impair various components of the immune system, including natural killer (NK) cell activity, cytokine production, balance in white blood cell populations, and immune responses to pathogens, tumors, or injury 87

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