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The logic is that any acute metabolic effects peak during waking hours rather than during sleep

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The semaglutide side effects users reported most often in clinical trials were: Nausea Diarrhea Vomiting Constipation Abdominal pain Headache Fatigue More than 20% of trial participants reported these side effects, with 44% reporting nausea and 30% reporting diarrhea compared to 24% or fewer for vomiting, constipation, and abdominal pain

In one study, those who underwent a stress management program lost significantly more weight