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Changes are quite likely more related to increased systemic inflammation, BBB disruption, and cognitive outcome deterioration (Silva et al., 2020)
While much is currently known about APAP hepatotoxicity regarding its epidemiology, risk factors, pharmacology and toxicology, diagnostics and treatment modalities, there remains a plethora of scientific questions that should be answered in order to improve the understanding of molecular and sub-molecular relationships and pathways that may offer new therapeutics to tackle this curable yet potentially devastating event
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