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They found that these supplements increased the production of beneficial SCFAs like acetate and propionate without changing the overall diversity or makeup of gut bacteria

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246 SIRT3, on the other hand, inhibits apoptosis and promotes cell growth, increases glycolytic metabolism, 247 maintains mitochondrial membrane integrity, 248 promotes mitochondrial DNA repair 249,250,251 and increases cell resistance to environmental stress

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These advances also align with the emerging paradigm of precision medicine in obesity, in which genetic predictors of response and adverse effects to GLP-1-based therapies may enable more individualized treatment strategies [24]