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however, supraphysiological histidine (at 100 mM), 8- to 80-fold higher than in our tumor models, induced outgrowth of murine hepatocarcinoma via histamine-mediated T cell exhaustion and stromal reprogramming 81

This theory is that free radicals, as by-products of mitochondrial oxidative metabolism, cause cumulative cellular damage that results in overall loss of organismal fitness over time

Always use bacteriostatic water for multi-dose vials

findings are not validated in humans

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