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Results Metabolite profiling in the motor cortex with TDP-43 pathology reveals energy deficiency and oxidative stress We previously identified major mitochondrial problems, especially within the corticospinal motor neurons (CSMN) of prpTDP-43 A315T mice 16 (Fig

Membranes were washed three times with PBS-T and incubated for 1 h at 2022 C with the corresponding horseradish peroxidase-labelled secondary antibodies: goat anti-rabbit IgG (H + L) (Vector Laboratories, BA-1000