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Description

Hypomorph mutations or knockdown of many cohesin genes (SMC1, SMC3, RAD21/SCC1, STAG2) are synthetic lethal with PARPi olaparib which are attributed to the overlapping role of cohesin and PARP1/2 in preventing replication fork collapse (Liu et al, 2018

Thomas JP, Geiger PG, Maiorino M, Ursini F, Girotti AW

doi: 10.1155/2012/216970

doi: 10.1007/s00384-014-2030-8 106 ZablockaBGoldspinkPHGoldspinkGGoreckiDC

the classical/mannose/alternative pathways in the C4bp-depleted NHS were evaluated for their complement activity using Wieslab complement system screen (SVAR) according to the manufacturers instructions

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