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In CD4 T helper cells, the 1,25(OH)DVDR axis suppresses Th1/Th17-associated cytokines such as IFN-, IL-17 A, and IL-22, while upregulating Th2-related cytokines including IL-4, IL-5, and IL-13, thus promoting a functional shift toward Th2 polarization [163,164,165]

Recent studies have revealed that kinases can act as molecular effectors that direct response pathways toward senescence or apoptosis [21]

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At the same time, patients who restrict protein may tend to eat more alkaline vegetables and fruits, thus further relieving systemic acidity (Frassetto 2001)