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In addition, receptors for ACTH (MC2R) are present in normal corticotrophs, allowing ultra-fast feedback regulation of the HPA axis (212)

Although clascoterone and spironolactone have similar chemical structures with a 4-ring backbone similar to that of DHT, 29,45 these compounds differ somewhat in their mechanisms of action (Figure 1) and are not considered to be substitutable with each other for clinical use

Nat Rev Neurosci 22:758776 Chieosilapatham P, Kiatsurayanon C, Umehara Y, Trujillo-Paez J, Peng G, Yue H, Nguyen L, Niyonsaba F (2021) Keratinocytes: innate immune cells in atopic dermatitis

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Enjoy the nourishing benefits of this cream for soft and supple skin