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Its anti-inflammatory effect is mediated by suppressing the TLR4/MyD88/NF-B pathway, which inhibits the phosphorylation of downstream p65 and inhibitor of NF-B (IB), causing downregulated MCP-1 expression and upregulated IL-13 secretion

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Though it can be derived from the comfrey plant, allantoin is produced synthetically for cosmetic products to ensure purity

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