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Dorn, C
This dose-tolerability relationship provides useful guidance for clinical protocol development
Human studies using Lactobacillus as a probiotic have often demonstrated decreased body weight and/or body fat in a strain-dependent manner (for a review of human studies, see Crovesy et al., 2017 58 ), suggesting that the NNMTi-and-LD-mediated changes to Lactobacillus relative abundance may be critical to NNMTi-mediated weight loss
extreme tiredness, lack of energy, muscle weakness, disturbed vision, low mood, hair loss and premature greying of hair
The disconnect between preclinical efficacy and human clinical outcomes remains unexplained and represents a significant limitation for potential therapeutic applications
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