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Interestingly, the most striking respiratory difference attributable to loss of GSH emerged upon treatment of Gclc fl/fl and Gclc fl/fl Mb1-Cre + FoB with the mitochondrial ionophore FCCP, which increases the OCR to the maximal respiration (i.e

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Mitochondrial damage may be caused by exposure to toxic substances such as heavy metals (mercury, lead), toxins, and air pollution