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With this compound, weight losses of up to 22% are generated in obese individuals [42], and several of the phase III SURPASS trials of patients with T2DM have shown reductions of HbA 1c to values at or below 5.7% (a completely normal value) in more than 50% of the patients, accompanied by weight losses in the order of 12% [43]

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Thus, it is not surprizing that mutations of hydrophobic residues, within AHs, to Ala or to hydrophilic residues (substitutions that decrease hydrophobic moment) inhibit the ability of fission proteins such as Arf1 (Krauss et al., 2008), Sar1p (Lee et al., 2005), endophilin A1 (Farsad et al., 2001

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