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The mechanism of endocrine disruption is due to negative interactions with various transcription factors, receptors and tissues that result in alterations of metabolic function
For a much deeper insight on the topic, the reader is advised to Pearson and Wienkerss Handbook of Drug Metabolism (currently in its 3rd edition by CRC Press)
Buse JB, DeFronzo RA, Rosenstock J et al (2016) The primary glucose-lowering effect of metformin resides in the gut, not the circulation: results from short-term pharmacokinetic and 12-week dose-ranging studies
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