Whereas the endocrine system is the main secretory pathway, GH is also expressed in many extrapituitary tissues in which it has autocrine and paracrine effects
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Since the PHH used for the three experiments were from the same 10-donor cell batch, it was reasonable to assume that the data are biologically and statistically comparable and can be combined in a single data pool for concentrationresponse analysis (U.S
Peptide signaling increases cellular activity, and jumping straight to high concentrations can overwhelm cells that aren't accustomed to that level of stimulation
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