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Therefore, BMP4 becomes a potential therapeutic target in CRC, especially in a diabetic context where high blood glucose significantly affects cancer progression through the BMP4 pathway

Densitometric values of the western blots were quantified by using ChemiDoc XRS + software Image Lab 5.1 (BioRad) and significance test was carried out using Students t -test

The glucagon receptor is particularly dose-sensitive

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This helps explain why statins are associated with: Higher fasting glucose Increased risk of insulin resistance A small but measurable increase in type 2 diabetes risk 3 Mitochondrial and energy effects Statins reduce production of CoQ10 , a compound essential for mitochondrial energy production