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Abbreviations ACR: American College of Rheumatology CNS: central nervous system GABA: gamma-aminobutyric acid Kv: voltage-gated potassium channels LFT: liver function test NMDA: N-methyl-D-aspartate Declarations Acknowledgement None

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After binding to its receptor, type I interferons activate the JAK/STAT signaling pathway, which in turn activates the IFI6 gene (58)