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This perspective has shifted substantially over the past 2 decades as accumulating evidence has demonstrated that both tissues secrete bioactive peptides that function as hormones, influencing glucose metabolism, energy expenditure, reproductive physiology, and aspects of aging

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In these 18- and 24-week studies, among patients who were not on an antihyperglycemic agent at study entry, the reductions from baseline in A1C were -0.7% and -0.8%, respectively, for those given JANUVIA, and -0.1% and -0.2%, respectively, for those given placebo

Hall, J

While effective for multiple chemical classes, this approach is largely inadequate for NAs