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In support of this muscle long-chain acyl-CoA content returned to basal overnight during the l-carnitine infusion visit (whereas it remained suppressed during the control visit), which suggests that beta-oxidation was indeed increased. In an attempt to discover the lowest amount of insulin needed to drive carnitine into muscle and activate the switch from carbohydrate oxidation to fatty acid oxidation, the Stephens Group undertook a study the reports of which are discussed in A threshold exists for the stimulatory effect of insulin on plasma L-carnitine clearance in humans

J Inherited Metab Dis 20 : 270285

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