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The increased cAMP levels in cardiac cells activate exchange protein directly activated by cAMP (EPAC) and protein kinase A (PKA), which regulate a multitude of downstream effectors involved in cardiac contractility, relaxation, and hypertrophy [14]

Literature Review Table 1: [7] Lee E, Padgett B

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Skin Pigmentation (Chromameter b*) The b* value captures yellow-to-orange pigmentation tone in the skin

Patients at high risk of colon cancer should undergo rigid proctoscopy, flexible sigmoidoscopy or colonoscopy.3,4 In our practice, we recommend endoscopic evaluation for patients older than age 40 with rectal bleeding, especially if they have a family history of colorectal cancer