The liver metabolizes and often deactivates many compounds before they can reach the rest of the body
The controlled human verdict is pending
Deficits in glutamate (mGluR5) and GABA (GABA-A) receptors are similarly more widespread in AD and PD, in contrast to LLD, and are observed in regions of greatest neurodegeneration in each case
The real questions are harder
Epileptogenesis is defined as the latent period between the initial brain insult and the first unprovoked seizure, where very intensive neuronal alterations take place, including oxidative stress, the expression of pro-inflammatory mediators, neurodegeneration, reactive gliosis, damage to the blood-brain barrier, increased epileptiform spiking, and spontaneous recurrent seizures (Borowicz-Reutt and Czuczwar 2020)