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Yes, certain drugs can cause hepatotoxicity or cardiovascular issues like hypertension or QT prolongation

Carroll MF, Schade DS

Stem cells for the skin are thought to arise from enlarged hair follicles

Therefore, the treatment strategies during phase II follow the treatments employed during phase I: babies should be treated with anti-inflammatory, neuroprotective, or nerve regenerating agents (e.g., nerve growth factor), and stem cell transplantation