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There is also the desire to fulfill the requirements of the 3Rs (Replace, Reduce, Refine) in animal studies, which includes the need to combine microsampling with sensitive assay methods that consume minimal sample (9)

PMID: 39125786

Metabolic Adaptation Metabolic adaptation is the bodys energy use slowdown post calorie loss or drug-assisted weight change

Key Research Characteristics: Extended half-life (~2030 hours vs ~1215 minutes for native IGF-1) due to reduced IGFBP binding Potent agonist at IGF-1R, studied for roles in cellular proliferation, differentiation, and survival signalling Investigated in models of muscle hypertrophy, neuroprotection, and metabolic regulation 83 amino acid analogue